David Mattey

Toxic Avenger / Noxious Offender

Debbie Rochon

Ms. Weiner

Clyde Lewis

Toxie (voice)

Heidi Sjursen

Sarah / Claire

Ron Jeremy

Mayor Goldberg

Tom Fulp

Painter

Paul Kyrmse

Sgt. Kabukiman / Evil Kabukiman

Stan Lee

Prologue / Epilogue Narrator (voice)

Joe Fleishaker

Chester / Lardass