John Barrymore

Dr. Henry Jekyll / Mr. Edward Hyde

Brandon Hurst

Sir George Carewe

Martha Mansfield

Millicent Carewe

Charles Lane

Dr. Richard Lanyon

Cecil Clovelly

Edward Enfield

Nita Naldi

Miss Gina

Louis Wolheim

Music Hall Proprietor

Alma Aiken

Extra (uncredited)

J. Malcolm Dunn

John Utterson (uncredited)