Sarah Silverman

Self

Nathan Barnatt

Homeless Man (segment "Lisa")

Lauren Lapkus

Girl 5 (segment "Lisa")

John C. Reilly

Father (segment "Ham")

Laura Silverman

Self (segment "Knickers")

Seth Rogen

Officer Durand (segment "Knickers")

Jade Catta-Preta

Mother (segment "Lisa")

Natasha Leggero

Girl 2 (segment "Lisa")