Neil deGrasse Tyson

Narrator

Chris Wedge

Scrat (voice)

Karen Disher

Scratazons (voice)

John Leguizamo

Sid (voice) (uncredited)

Jennifer Lopez

Shira (voice) (uncredited)

Simon Pegg

Buck (voice) (uncredited)

Ray Romano

Manny (voice) (uncredited)

Adam Devine

Julian (voice) (uncredited)