Christopher Daniel Barnes

Peter Parker / Spider-Man (voice)

Hank Azaria

Eddie Brock / Venom (voice)

Sara Ballantine

Mary Jane Watson (voice)

Ed Asner

J. Jonah Jameson (voice)

James Avery

Jim Rhodes / War Machine (voice)

Roscoe Lee Browne

Kingpin (voice)

Scott Cleverdon

Cletus Kasady / Carnage (voice)

Robert Hays

Tony Stark / Iron Man (voice)

Joseph Campanella

Dr. Curt Connors (voice)