Ryan Reynolds

Wade Wilson / Deadpool / Juggernaut (voice)

Josh Brolin

Cable

Morena Baccarin

Vanessa

Julian Dennison

Firefist

Zazie Beetz

Domino

T.J. Miller

Weasel

Leslie Uggams

Blind Al

Karan Soni

Dopinder

Brianna Hildebrand

Negasonic Teenage Warhead