Hugh Jackman

Gabriel Van Helsing (voice)

Robbie Coltrane

Mr. Hyde (voice)

David Wenham

Carl (voice)

Grey DeLisle

First Victim (voice)

Dwight Schultz

Dr. Jekyll (voice)

John DiMaggio

Coachman (voice)

Scott Mosenson

Palastwache (voice)

Alun Armstrong

Cardinal Jinetta (voice)

Roger L. Jackson

Gentleman (voice)